Flavio Cobolli, Italy's 12th-ranked player, enters the Rome first round against Tomás Agustín Tirante seeking to build momentum on his home clay. Cobolli's recent form shows mixed results, with wins over Medvedev and Vallejo offset by losses to Zverev and Shelton in straight sets. The Italian will look to capitalize on home-court advantage and his higher seeding in this first meeting with Tirante. Clay is traditionally a strong surface for Italian players, and Cobolli will be aiming to advance deep into Rome.

Tomás Agustín Tirante, ranked 69th from Argentina, travels to Rome as an unseeded challenger in the first round against Cobolli. Tirante has shown competitive tennis recently, defeating Cadenasso, Paul, and Bautista-Agut, though he struggled against Norrie and Burruchaga in his last two outings. This marks the first career meeting between the two players, with no head-to-head history to guide expectations. The Argentine will need to apply aggressive clay-court tennis to test the higher-ranked home favorite.