Dominik Altmaier, ranked 52nd from Germany, enters the Monte Carlo first round against Tomáš Machac with mixed recent form. The German clay-courter has won two of his last five matches, including a straight-sets victory over Prizmic, though he suffered consecutive losses to Marozsan and Medjedovic. Altmaier holds an 0–1 head-to-head record against Machac. At Pinnacle odds of 2.34, the home player is favored in this first-round clay clash.

Tomáš Machac, ranked 55th from the Czech Republic, arrives at Monte Carlo on a disappointing four-match losing streak across his last five outings. The Czech player's only recent win came against Nava in a three-set affair, while he fell to quality opponents including Sinner, Musetti, Moutet, and Jodar. Machac holds a 1–0 advantage in the H2H series against Altmaier and faces odds of 1.66 in this first-round clay encounter.